Identification of novel F₂-isoprostane metabolites by specific UDP-glucuronosyltransferases.

ABSTRACT: UDP-glucuronosyltransferases (UGTs) catalyze the conjugation of glucuronic acid with endogenous and exogenous lipophilic small molecules to facilitate their inactivation and excretion from the body. This represents approximately 35 % of all phase II metabolic transformations. Fatty acids and their oxidized eicosanoid derivatives can be metabolized by UGTs. F₂-isoprostanes (F₂-IsoPs) are eicosanoids formed from the free radical oxidation of arachidonic acid. These molecules are potent vasoconstrictors and are widely used as biomarkers of endogenous oxidative damage. An increasing body of evidence demonstrates the efficacy of measuring the β-oxidation metabolites of F₂-IsoPs rather than the unmetabolized F₂-IsoPs to quantify oxidative damage in cer

SUBMITTER: Milne GL 

PROVIDER: S-EPMC10821610 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature