Integrating multiple lines of evidence to assess the effects of maternal BMI on pregnancy and perinatal outcomes.

ABSTRACT:

Background

Higher maternal pre-pregnancy body mass index (BMI) is associated with adverse pregnancy and perinatal outcomes. However, whether these associations are causal remains unclear.

Methods

We explored the relation of maternal pre-/early-pregnancy BMI with 20 pregnancy and perinatal outcomes by integrating evidence from three different approaches (i.e. multivariable regression, Mendelian randomisation, and paternal negative control analyses), including data from over 400,000 women.

Results

All three analytical approaches supported associations of higher maternal BMI with lower odds of maternal anaemia, delivering a small-for-gestational-age baby and initiating breastfeeding, but higher odds of hypertensive disorders of pregnancy, gestational hypertension, preecl

SUBMITTER: Borges MC 

PROVIDER: S-EPMC10823651 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature