Lower muscle mitochondrial energetics is associated with greater phenotypic frailty in older women and men: the Study of Muscle, Mobility and Aging.

ABSTRACT:

Background

Phenotypic frailty syndrome identifies older adults at greater risk for adverse health outcomes. Despite the critical role of mitochondria in maintaining cellular function, including energy production, the associations between muscle mitochondrial energetics and frailty have not been widely explored in a large, well-phenotyped, older population.

Methods

The Study of Muscle, Mobility and Aging (SOMMA) assessed muscle energetics in older adults (N = 879, mean age = 76.3 years, 59.2% women). ³¹Phosporous magnetic resonance spectroscopy measured maximal production of adenosine triphosphate (ATP_max) in vivo, while ex vivo high-resolution respirometry of permeabilized muscle fibers from the vastus lateralis measured maximal oxygen consumption suppo

SUBMITTER: Mau T 

PROVIDER: S-EPMC10828481 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature