Early excitatory-inhibitory cortical modifications following skill learning are associated with motor memory consolidation and plasticity overnight.

ABSTRACT: Consolidation of motor memories is vital to offline enhancement of new motor skills and involves short and longer-term offline processes following learning. While emerging evidence link glutamate and GABA dynamics in the primary motor cortex (M1) to online motor skill practice, its relationship with offline consolidation processes in humans is unclear. Using two-day repeated measures of behavioral and multimodal neuroimaging data before and following motor sequence learning, we show that short-term glutamatergic and GABAergic responses in M1 within minutes after learning were associated with longer-term learning-induced functional, structural, and behavioral modifications overnight. Furthermore, Glutamatergic and GABAergic modifications were differentially associated with different facets

SUBMITTER: Eisenstein T 

PROVIDER: S-EPMC10828487 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature