Serpin peptidase inhibitor, clade E, member 2 is associated with malignant progression and clinical prognosis in oral squamous cell carcinoma.

ABSTRACT:

Background/purpose

The serpin peptidase inhibitor, clade E, member 2 (SERPINE2), is upregulated in breast cancer, prostate cancer, and urothelial carcinoma; however, limited information exists regarding its expression in oral cancer. Therefore, this study aimed to analyze the association between SERPINE2 expression and oral squamous cell carcinoma (OSCC) outcomes.

Materials and methods

SERPINE2 mRNA and protein expression in patients with head and neck squamous cell carcinoma and OSCC were investigated using online databases and tissue-array analysis. Its relationship with clinicopathological characteristics, OSCC prognosis and its biological function in OSCC cells were explored.

Results

Analysis using online databases revealed higher SERPINE2 expression

SUBMITTER: Chuang HW 

PROVIDER: S-EPMC10829680 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature