Systematic review and meta-analysis of the genetics of peripheral arterial disease.

ABSTRACT:

Background

Peripheral artery disease (PAD) impacts more than 200 million people worldwide. The understanding of the genetics of the disease and its clinical implications continue to evolve. This systematic review provides a comprehensive summary of all DNA variants that have been studied in association with the diagnosis and progression of PAD, with a meta-analysis of the ones replicated in the literature.

Methods

A systematic review of all studies examining DNA variants associated with the diagnosis and progression of PAD was performed. Candidate gene and genome-wide association studies (GWAS) were included. A meta-analysis of 13 variants derived from earlier smaller candidate gene studies of the diagnosis of PAD was performed. The literature on the progression of PAD was l

SUBMITTER: Ochoa Chaar CI 

PROVIDER: S-EPMC10832467 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature