Changes of tRNA-Derived Fragments by Alzheimer's Disease in Cerebrospinal Fluid and Blood Serum.

ABSTRACT:

Background

Alzheimer's disease (AD) is the most common type of dementia, affecting individuals over 65. AD is also a multifactorial disease, with disease mechanisms incompletely characterized, and disease-modifying therapies are marginally effective. Biomarker signatures may shed light on the diagnosis, disease mechanisms, and the development of therapeutic targets. tRNA-derived RNA fragments (tRFs), a family of recently discovered small non-coding RNAs, have been found to be significantly enhanced in human AD hippocampus tissues. However, whether tRFs change in body fluids is unknown.

Objective

To investigate whether tRFs in body fluids are impacted by AD.

Methods

We first used T4 polynucleotide kinase-RNA-seq, a modified next-generation sequencing technique, to iden

SUBMITTER: Wu W 

PROVIDER: S-EPMC10832608 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature