Evaluation of AR, AR-V7, and p160 family as biomarkers for prostate cancer: insights into the clinical significance and disease progression.

ABSTRACT:

Purpose

To assess the role of the p160 family, AR, and AR-V7 in different initial presentations of prostate cancer and their association with clinical endpoints related to tumor progression.

Methods

The study sample comprises 155 patients who underwent radical prostatectomy and 11 healthy peripheral zone biopsies as the control group. Gene expression was quantified by qPCR from the tissue specimens. The statistical analysis investigated correlations between gene expression levels, associations with disease presence, and clinicopathological features. Additionally, ROC curves were applied for distinct PCa presentations, and time-to-event analysis was used for clinical endpoints.

Results

The AR-V7 diagnostic performance for any PCa yielded an AUC of 0.77 (p < 0.05). For

SUBMITTER: Pimenta R 

PROVIDER: S-EPMC10837222 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature