Single nucleotide polymorphism within chromosome 8q24 is associated with prostate cancer development in Saudi Arabia.

ABSTRACT:

Objective

Genome-wide association studies have demonstrated that single nucleotide polymorphisms (SNPs) are important risk factors for the development of prostate cancer (PCa). Preliminary studies have suggested that the incidence of PCa in Saudi males is low but is probably familial or genetically related.

Methods

To identify any possible association of SNP with PCa development in Saudi patients, we investigated a group of SNPs in Saudi PCa patients (n=85) and compared the outcomes to healthy normal controls (n=115) and nodular hyperplasia patients (n=120). DNA was extracted from paraffin-embedded formalin fixed tissue or whole blood from both patients' groups and healthy control group. A total of thirteen SNPs were genotyped using TaqMan® minor groove

SUBMITTER: Osman AE 

PROVIDER: S-EPMC10837665 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature