Ferritin-mediated neutrophil extracellular traps formation and cytokine storm via macrophage scavenger receptor in sepsis-associated lung injury.

ABSTRACT:

Background

Sepsis is a severe systemic inflammatory disorder manifested by a dysregulated immune response to infection and multi-organ failure. Numerous studies have shown that elevated ferritin levels exist as an essential feature during sepsis and are able to suggest patients' prognoses. At the same time, the specific mechanism of ferritin-induced inflammatory injury remains unclear.

Methods

Hyper-ferritin state during inflammation was performed by injecting ferritin into a mouse model and demonstrated that injection of ferritin could induce a systemic inflammatory response and increase neutrophil extracellular trap (NET) formation.Padi4^-/-, Elane^-/- and Cybb^-/- mice were used for the NETs formation experiment. Western blot, immunofluoresce

SUBMITTER: Zhang H 

PROVIDER: S-EPMC10837893 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature