Dysfunction of Drosophila mitochondrial carrier homolog (Mtch) alters apoptosis and disturbs development.
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SUBMITTER: Gonzalez C
PROVIDER: S-EPMC10839352 | biostudies-literature | 2024 Feb
REPOSITORIES: biostudies-literature
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Dysfunction of Drosophila mitochondrial carrier homolog (Mtch) alters apoptosis and disturbs development.
González Cristina C Martínez-Sánchez Lidia L Clemente Paula P Toivonen Janne Markus JM Arredondo Juan José JJ Fernández-Moreno Miguel Ángel MÁ Carrodeguas José Alberto JA
FEBS open bio 20231219 2
Mitochondrial carrier homologs 1 (MTCH1) and 2 (MTCH2) are orphan members of the mitochondrial transporter family SLC25. Human MTCH1 is also known as presenilin 1-associated protein, PSAP. MTCH2 is a receptor for tBid and is related to lipid metabolism. Both proteins have been recently described as protein insertases of the outer mitochondrial membrane. We have depleted Mtch in Drosophila and show here that mutant flies are unable to complete development, showing an excess of apoptosis during pu ...[more]
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