Graves disease is associated with increased risk of clinical Alzheimer's disease: evidence from the Medicare system.

ABSTRACT:

Background

Identification of modifiable risk factors for Alzheimer's Disease (AD) onset is an important aspect of controlling the burden imposed by this disease on an increasing number of older U.S. adults. Graves disease (GD), the most common cause of hyperthyroidism in the U.S., has been hypothesized to be associated with increased AD risk, but there is no consensus. In this study, we explore the link between GD and risk of clinical AD.

Methods

Cox and Fine-Grey models were applied to a retrospective propensity-score-matched cohort of 19,798 individuals with GD drawn from a nationally representative 5% sample of U.S. Medicare beneficiaries age 65 + over the 1991-2020 period.

Results

Results showed that the presence of GD was associated with a higher risk of AD (Haza

SUBMITTER: Yashkin AP 

PROVIDER: S-EPMC10840251 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature