Periodontitis in ischemic stroke: impact of Porphyromonas gingivalis on thrombus composition and ischemic stroke outcomes.

ABSTRACT:

Background

Periodontitis is associated with an increased risk of ischemic stroke, but the mechanisms underlying this association remain unclear.

Objectives

Our objective was to determine whether Porphyromonas gingivalis (Pg), a periodontal bacterium, could be detected within thrombus aspirates, modify thrombus composition, and endovascular therapy responses.

Methods

The presence of Pg gingipain in 175 consecutive thrombi from patients with large vessel occlusion stroke enrolled in the multicenter research cohort compoCLOT was investigated by immunostaining. Thrombus blood cell composition according to gingipain status was analyzed in a subset of 63 patients.

Results

Pg gingipain immunostaining was positive in 33.7% of thrombi (95% CI, 26.7%-40.8%). The p

SUBMITTER: Freiherr Von Seckendorff A 

PROVIDER: S-EPMC10840352 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature