DNA from multiple viral species is associated with Alzheimer's disease risk.

ABSTRACT:

Introduction

Multiple infectious agents, including viruses, bacteria, fungi, and protozoa, have been linked to Alzheimer's disease (AD) risk by independent lines of evidence. We explored this association by comparing the frequencies of viral species identified in a large sample of AD cases and controls.

Methods

DNA sequence reads that did not align to the human genome in sequences were mapped to viral reference sequences, quantified, and then were tested for association with AD in whole exome sequences (WES) and whole genome sequences (WGS) datasets.

Results

Several viruses were significant predictors of AD according to the machine learning classifiers. Subsequent regression analyses showed that herpes simplex type 1 (HSV-1) (odds ratio [OR] = 3.71, p = 8.03 × 10-4) a

SUBMITTER: Tejeda M 

PROVIDER: S-EPMC10840621 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature