Dataset Information

Long-term non-progression and risk factors for disease progression among children living with HIV in Botswana and Uganda: A retrospective cohort study.

ABSTRACT:

Objectives

We utilize a large retrospective study cohort derived from electronic medical records to estimate the prevalence of long-term non-progression (LTNP) and determine the factors associated with progression among children infected with HIV in Botswana and Uganda.

Methods

Electronic medical records from large tertiary HIV clinical centers in Botswana and Uganda were queried to identify LTNP children 0-18 years enrolled between June 2003 and May 2014 and extract demographic and nutritional parameters. Multivariate subdistribution hazard analyses were used to examine demographic factors and nutritional status in progression in the pre-antiretroviral therapy era.

Results

Between the two countries, 14,246 antiretroviral therapy-naïve children infected with HIV were enrolled into clinical care. The overall proportion of LTNP was 6.3% (9.5% in Botswana vs 5.9% in Uganda). The median progression-free survival for the cohort was 6.3 years, although this was lower in Botswana than in Uganda (6.6 vs 8.8 years; P <0.001). At baseline, the adjusted subdistribution hazard ratio (aHR_sd) of progression was increased among underweight children (aHR_sd 1.42; 95% confidence interval [CI]: 1.32-1.53), enrolled after 2010 (aHR_sd 1.32; 95% CI 1.22-1.42), and those from Botswana (aHR_sd 2; 95% CI 1.91-2.10).

Conclusions

In our study, the prevalence of pediatric LTNP was lower than that observed among adult populations, but progression-free survival was higher than expected. Underweight, year of enrollment into care, and country of origin are independent predictors of progression among children.

SUBMITTER: Kyobe S

PROVIDER: S-EPMC10843817 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature

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Publications

Long-term non-progression and risk factors for disease progression among children living with HIV in Botswana and Uganda: A retrospective cohort study.

Kyobe Samuel S Kisitu Grace G Mwesigwa Savannah S Farirai John J Katagirya Eric E Retshabile Gaone G Williams Lesedi L Mirembe Angela A Ketumile Lesego L Wayengera Misaki M Mukisa John J Sebetso Gaseene G Diphoko Thabo T Amujal Marion M Kigozi Edgar E Katabazi Fred F Oceng Ronald R Mlotshwa Busisiwe B Morapedi Koketso K Nsangi Betty B Wampande Edward E Tsimako Masego M Brown Chester C Kasvosve Ishmael I Joloba Moses M Anabwani Gabriel G Mpoloka Sununguko S Mardon Graeme G Kekitiinwa Adeodata A Hanchard Neil A NA Kyosiimire-Lugemwa Jacqueline J Matshaba Mogomotsi M Kiragga Dithan D

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 20231128

<h4>Objectives</h4>We utilize a large retrospective study cohort derived from electronic medical records to estimate the prevalence of long-term non-progression (LTNP) and determine the factors associated with progression among children infected with HIV in Botswana and Uganda.<h4>Methods</h4>Electronic medical records from large tertiary HIV clinical centers in Botswana and Uganda were queried to identify LTNP children 0-18 years enrolled between June 2003 and May 2014 and extract demographic a ...[more]

PMID: 38036259

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Dataset Information

Long-term non-progression and risk factors for disease progression among children living with HIV in Botswana and Uganda: A retrospective cohort study.

Objectives

Methods

Results

Conclusions

Publications

Long-term non-progression and risk factors for disease progression among children living with HIV in Botswana and Uganda: A retrospective cohort study.

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