Ontology highlight
ABSTRACT:
SUBMITTER: Cai Y
PROVIDER: S-EPMC10844047 | biostudies-literature | 2024 Feb
REPOSITORIES: biostudies-literature
Cai Yuanqing Y Chen Yi Y Zhang Guangyang G Lin Yi Y Zhang Jianan J Liang Jialin J Lv Leifeng L Wang Yong Y Fang Xinyu X Dang Xiaoqian X
iScience 20240119 2
Magnesium (Mg)-based conduits have gained more attention in repairing peripheral nerve defects. However, they are limited due to poor corrosion resistance and rapid degradation rate. To tackle this issue, glial cell line-derived neurotrophic factor (GDNF)- Gelatin methacryloyl (Gel)/hydroxylapatite (HA)-Mg nerve conduit was developed and implanted in sciatic nerve defect model in Sprague-Dawley (SD) rats. The sciatic functional index measurement showed that the GDNF-Gel/HA-Mg nerve conduit effec ...[more]