DNA framework signal amplification platform-based high-throughput systemic immune monitoring.

ABSTRACT: Systemic immune monitoring is a crucial clinical tool for disease early diagnosis, prognosis and treatment planning by quantitative analysis of immune cells. However, conventional immune monitoring using flow cytometry faces huge challenges in large-scale sample testing, especially in mass health screenings, because of time-consuming, technical-sensitive and high-cost features. However, the lack of high-performance detection platforms hinders the development of high-throughput immune monitoring technology. To address this bottleneck, we constructed a generally applicable DNA framework signal amplification platform (DSAP) based on post-systematic evolution of ligands by exponential enrichment and DNA tetrahedral framework-structured probe design to achieve high-sensitive detection for diver

SUBMITTER: Chen Y 

PROVIDER: S-EPMC10847453 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature