Maternal PM2.5 exposure is associated with preterm birth and gestational diabetes mellitus, and mitochondrial OXPHOS dysfunction in cord blood.

ABSTRACT: Maternal exposure to fine particulate matter (PM_2.5) is associated with adverse pregnancy and neonatal health outcomes. To explore the mechanism, we performed mRNA sequencing of neonatal cord blood. From an ongoing prospective cohort, Air Pollution on Pregnancy Outcome (APPO) study, 454 pregnant women from six centers between January 2021 and June 2022 were recruited. Individual PM_2.5 exposure was calculated using a time-weighted average model. In the APPO study, age-matched cord blood samples from the High PM_2.5 (˃15 ug/m³; n = 10) and Low PM_2.5 (≤ 15 ug/m³; n = 30) groups were randomly selected for mRNA sequencing. After selecting genes with differential expression in the two groups (p-value < 0.05 and log2 fold change > 1

SUBMITTER: You YA 

PROVIDER: S-EPMC10850187 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature