<i>HLA-DPA1*02:01~B1*01:01</i> is a risk haplotype for primary sclerosing cholangitis mediating activation of NKp44+ NK cells.

ABSTRACT:

Objective

Primary sclerosing cholangitis (PSC) is characterised by bile duct strictures and progressive liver disease, eventually requiring liver transplantation. Although the pathogenesis of PSC remains incompletely understood, strong associations with HLA-class II haplotypes have been described. As specific HLA-DP molecules can bind the activating NK-cell receptor NKp44, we investigated the role of HLA-DP/NKp44-interactions in PSC.

Design

Liver tissue, intrahepatic and peripheral blood lymphocytes of individuals with PSC and control individuals were characterised using flow cytometry, immunohistochemical and immunofluorescence analyses. HLA-DPA1 and HLA-DPB1 imputation and association analyses were performed in 3408 individuals with PSC and 34 213 controls. NK cell activat

SUBMITTER: Zecher BF 

PROVIDER: S-EPMC10850656 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature