Livin expression promotes keratinocyte release of inflammatory mediators in psoriasis.

ABSTRACT:

Background

Psoriasis is a prevalent, long-term skin condition characterized by inflammation. Keratinocytes (KCs) are important effector cells that release inflammatory factors and chemokines to promote the inflammatory cascade in psoriasis. However, the mechanisms underlying the activation of KCs in psoriasis remain unclear. Livin suppresses apoptotic proteins and directly affects the growth and spread of cancer cells. Livin expression reportedly increases significantly in lesions of patients with psoriasis; however, its specific role in KC activation remains unknown. This study aimed to examine the impact of Livin on KC activation and the subsequent release of inflammatory mediators.

Methods

Immunofluorescence staining, reverse transcription-quantitative polymerase chain re

SUBMITTER: Che D 

PROVIDER: S-EPMC10853572 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature