Allostatic load and chronic pain: a prospective finding from the national survey of midlife development in the United States, 2004-2014.

ABSTRACT:

Background

Previous research has demonstrated a correlation between chronic stress and chronic pain (CP). However, there have been few studies examining the prospective association of allostatic load (AL)-the biological processes related to stress-with CP.

Methods

We firstly conducted latent class analysis to identify phenotypes of AL using a community-dwelling sample, the Midlife in the United States. Multinomial logistic regression models were used to examine the prospective association between phenotypes of AL at MIDUS 2 biomarker project and the presence of CP, CP interference and the number of CP sites at MIDUS 3.

Results

Three phenotypes of AL, low biological dysregulation, parasympathetic dysregulation and metabolic dysregulation, were identified. Compared to l

SUBMITTER: Liang Y 

PROVIDER: S-EPMC10854121 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature