Unknown

Dataset Information

0

Decurarization After Thoracic Anesthesia using sugammadex compared to neostigmine (DATA trial): a multicenter randomized double-blinded controlled trial.


ABSTRACT:

Background

Thoracic surgery is a high-risk surgery especially for the risk of postoperative pulmonary complications. Postoperative residual paralysis has been shown to be a risk factor for pulmonary complications. Nevertheless, there are few data in the literature concerning the use of neuromuscular blocking agent antagonists in patients undergoing lung surgery.

Methods

Seventy patients were randomized in three Italian centers to receive sugammadex or neostigmine at the end of thoracic surgery according to the depth of the residual neuromuscular block. The primary outcome was the time from reversal administration to a train-of-four ratio (TOFR) of 0.9. Secondary outcomes were the time to TOFR of 1.0, to extubation, to postanesthesia unit (PACU) discharge, postoperative complications until 30 days after surgery, and length of hospital stay.

Results

Median time to recovery to a TOFR of 0.9 was significantly shorter in the sugammadex group compared to the neostigmine one (88 vs. 278 s - P < 0.001). The percentage of patients who recovered to a TOFR of 0.9 within 5 min from reversal administration was 94.4% and 58.8% in the sugammadex and neostigmine groups, respectively (P < 0.001). The time to extubation, but not the PACU stay time, was significantly shorter in the sugammadex group. No differences were found between the study groups as regards postoperative complications and length of hospital stay. The superiority of sugammadex in shortening the recovery time was confirmed for both deep/moderate and shallow/minimal neuromuscular block.

Conclusions

Among patients undergoing thoracic surgery, sugammadex ensures a faster recovery from the neuromuscular block and earlier extubation compared to neostigmine.

SUBMITTER: Piccioni F 

PROVIDER: S-EPMC10854138 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature

altmetric image

Publications

Decurarization After Thoracic Anesthesia using sugammadex compared to neostigmine (DATA trial): a multicenter randomized double-blinded controlled trial.

Piccioni Federico F   Rosboch Giulio L GL   Coccia Cecilia C   Donati Ilaria I   Proto Paolo P   Ceraolo Edoardo E   Pierconti Federico F   Pagano Martina M   Vernocchi Daniele D   Valenza Franco F   Rocca Giorgio Della GD  

Journal of anesthesia, analgesia and critical care 20240208 1


<h4>Background</h4>Thoracic surgery is a high-risk surgery especially for the risk of postoperative pulmonary complications. Postoperative residual paralysis has been shown to be a risk factor for pulmonary complications. Nevertheless, there are few data in the literature concerning the use of neuromuscular blocking agent antagonists in patients undergoing lung surgery.<h4>Methods</h4>Seventy patients were randomized in three Italian centers to receive sugammadex or neostigmine at the end of tho  ...[more]

Similar Datasets

| S-EPMC10391073 | biostudies-literature
| S-EPMC10150384 | biostudies-literature
| S-EPMC6800991 | biostudies-literature
| S-EPMC2944304 | biostudies-literature
| S-EPMC9608962 | biostudies-literature
| S-EPMC8423370 | biostudies-literature
| S-EPMC9286967 | biostudies-literature
| S-EPMC8576081 | biostudies-literature
| S-EPMC8815456 | biostudies-literature
| S-EPMC8771225 | biostudies-literature