BP-M345 as a Basis for the Discovery of New Diarylpentanoids with Promising Antimitotic Activity.

ABSTRACT: Recently, the diarylpentanoid BP-M345 (5) has been identified as a potent in vitro growth inhibitor of cancer cells, with a GI₅₀ value between 0.17 and 0.45 µM, showing low toxicity in non-tumor cells. BP-M345 (5) promotes mitotic arrest by interfering with mitotic spindle assembly, leading to apoptotic cell death. Following on from our previous work, we designed and synthesized a library of BP-M345 (5) analogs and evaluated the cell growth inhibitory activity of three human cancer cell lines within this library in order to perform structure-activity relationship (SAR) studies and to obtain compounds with improved antimitotic effects. Four compounds (7, 9, 13, and 16) were active, and the growth inhibition eff

SUBMITTER: Moreira J 

PROVIDER: S-EPMC10855865 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature