Treatment of Double-Refractory Chronic Lymphocytic Leukemia-An Unmet Clinical Need.
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ABSTRACT:
SUBMITTER: Zygmunciak P
PROVIDER: S-EPMC10855898 | biostudies-literature | 2024 Jan
REPOSITORIES: biostudies-literature
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Treatment of Double-Refractory Chronic Lymphocytic Leukemia-An Unmet Clinical Need.
Zygmunciak Przemysław P Robak Tadeusz T Puła Bartosz B
International journal of molecular sciences 20240127 3
Recent years have seen significant improvement in chronic lymphocytic leukemia (CLL) management. Targeting B-cell lymphoma (BCL-2) and Bruton's kinase (BTK) have become the main strategies to restrain CLL activity. These agents are generally well tolerated, but the discontinuation of these therapies happens due to resistance, adverse effects, and Richter's transformation. A growing population of patients who have previously used both BTK inhibitors and BCL2 suffer from the constriction of the fo ...[more]
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