A Kpna1-deficient psychotropic drug-induced schizophrenia model mouse for studying gene-environment interactions.

ABSTRACT: KPNA1 is a mediator of nucleocytoplasmic transport that is abundantly expressed in the mammalian brain and regulates neuronal differentiation and synaptic function. De novo mutations in Kpna1 have been identified using genome-wide association studies in humans with schizophrenia; however, it remains unclear how KPNA1 contributes to schizophrenia pathogenesis. Recent studies have suggested a complex combination of genetic and environmental factors that are closely related to psychiatric disorders. Here, we found that subchronic administration of phencyclidine, a psychotropic drug, induced vulnerability and behavioral abnormalities consistent with the symptoms of schizophrenia in Kpna1-deficient mice. Microarray assessment revealed that the expression levels of dopamine d1/d2 receptors, an R

SUBMITTER: Nomiya H 

PROVIDER: S-EPMC10858057 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature