Genome-wide Association Meta-analysis of Childhood and Adolescent Internalizing Symptoms.

ABSTRACT:

Objective

To investigate the genetic architecture of internalizing symptoms in childhood and adolescence.

Method

In 22 cohorts, multiple univariate genome-wide association studies (GWASs) were performed using repeated assessments of internalizing symptoms, in a total of 64,561 children and adolescents between 3 and 18 years of age. Results were aggregated in meta-analyses that accounted for sample overlap, first using all available data, and then using subsets of measurements grouped by rater, age, and instrument.

Results

The meta-analysis of overall internalizing symptoms (INT_overall) detected no genome-wide significant hits and showed low single nucleotide polymorphism (SNP) heritability (1.66%, 95% CI = 0.84-2.48%, n_effective = 132,260). Strat

SUBMITTER: Jami ES 

PROVIDER: S-EPMC10859168 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature