Ir(III) Half-Sandwich Photosensitizers with a π-Expansive Ligand for Efficient Anticancer Photodynamic Therapy.

ABSTRACT: One approach to reduce the side effects of chemotherapy in cancer treatment is photodynamic therapy (PDT), which allows spatiotemporal control of the cytotoxicity. We have used the strategy of coordinating π-expansive ligands to increase the excited state lifetimes of Ir(III) half-sandwich complexes in order to facilitate the generation of ¹O₂. We have obtained derivatives of formulas [Cp*Ir(C^∧N)Cl] and [Cp*Ir(C^∧N)L]BF₄ with different degrees of π-expansion in the C^∧N ligands. Complexes with the more π-expansive ligand are very effective photosensitizers with phototoxic indexes PI > 2000. Furthermore, PI values of 63 were achieved with red light. Time-dependent density functional theory (TD-DFT) calculations nicely explain t

SUBMITTER: Gonzalo-Navarro C 

PROVIDER: S-EPMC10859961 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature