Potassium homeostasis and therapeutic intervention with sodium zirconium cyclosilicate: A model-informed drug development case study.

ABSTRACT: Potassium (K⁺ ) is the main intracellular cation in the body. Elevated K⁺ levels (hyperkalemia) increase the risk of life-threatening arrhythmias and sudden cardiac death. However, the details of K⁺ homeostasis and the effects of orally administered K⁺ binders, such as sodium zirconium cyclosilicate (SZC), on K⁺ redistribution and excretion in patients remain incompletely understood. We built a fit-for-purpose systems pharmacology model to describe K⁺ homeostasis in hyperkalemic subjects and capture serum K⁺ (sK⁺ ) dynamics in response to acute and chronic administration of SZC. The resulting model describes K⁺ distribution in the gastrointestinal (GI) tract, blood, and extracellular and intr

SUBMITTER: Clegg LE 

PROVIDER: S-EPMC10864923 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature