Assessing the Labeling Information on Drugs Associated With Suicide Risk: Systematic Review.

ABSTRACT:

Background

Drug-induced suicide (DIS) is a severe adverse drug reaction (ADR). Although clinical trials have provided evidence on DIS, limited investigations have been performed on rare ADRs, such as suicide.

Objective

We aimed to systematically review case reports on DIS to provide evidence-based drug information.

Methods

We searched PubMed to obtain case reports regarding DIS published until July 2021. Cases resulting from drugs that are no longer used or are nonapproved, substance use, and suicidal intentions were excluded. The quality of each case report was assessed using the CASE (Case Reports) checklist. We extracted data regarding demographics, medication history, suicide symptoms, and symptom improvement and evaluated the causality of DIS using the Naranjo sc

SUBMITTER: Jeon SM 

PROVIDER: S-EPMC10865198 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature