Synergistic effect of albuminuria on atherosclerosis in patients with primary aldosteronism.

ABSTRACT:

Background

Primary aldosteronism (PA) has been associated with atherosclerosis beyond the extent of essential hypertension, but the impact of albuminuria remains unknown.

Objective

To investigate the effect of concomitant albuminuria on arterial stiffness in PA.

Design

Prospective cohort study.

Methods

A prospective cohort study was conducted to evaluate the association of albuminuria (>30 mg/g in morning spot urine) with arterial stiffness, as measured non-invasively by pulse wave velocity (PWV) in patients with PA. Propensity score matching (PSM) with age, sex, diabetes, systolic and diastolic blood pressure, creatinine, potassium, number of antihypertensive medications, and hypertension history was used to balance baseline characteristics. The effects of alb

SUBMITTER: Kao TW 

PROVIDER: S-EPMC10867404 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature