Emerging role of vitamin D₃ in alleviating intestinal structure injury caused by Aeromonas hydrophila in grass carp (Ctenopharyngodon idella).

ABSTRACT: Bacterial pathogens destroy the structural integrity of functional organs in fish, leading to severe challenges in the aquaculture industry. Vitamin D₃ (VD₃) prevents bacterial infections and strengthens immune system function via vitamin D receptor (VDR). However, the correlation between VD₃/VDR and the structural integrity of functional organs remains unclarified. This study aimed to investigate the influence of VD₃ supplementation on histological characteristics, apoptosis, and tight junction characteristics in fish intestine during pathogen infection. A total of 540 healthy grass carp (257.24 ± 0.63 g) were fed different levels of VD₃ (15.2, 364.3, 782.5, 1,167.9, 1,573.8, and 1,980.1 IU/kg) for 70 d. Subsequently, fish were challe

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC10867611 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature