GDF15 is a dynamic biomarker of the integrated stress response in the central nervous system.

ABSTRACT:

Aim

Characterize Growth Differentiation Factor 15 (GDF15) as a secreted biomarker of the integrated stress response (ISR) within the central nervous system (CNS).

Methods

We determined GDF15 levels utilizing in vitro and in vivo neuronal systems wherein the ISR was activated. Primarily, we used the murine model of vanishing white matter disease (VWMD), a neurological disease driven by persistent ISR in the CNS, to establish a link between levels of GDF15 in the cerebrospinal fluid (CSF) and ISR gene expression signature in the CNS. GDF15 was also determined in the CSF of VWM patients.

Results

GDF15 expression was increased concomitant to ISR activation in stress-induced primary astrocytes as well as in retinal ganglion cells following optic nerve crush, while treatmen

SUBMITTER: Asundi J 

PROVIDER: S-EPMC10867791 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature