Common genetic risk for Parkinson's disease and dysfunction of the endo-lysosomal system.

ABSTRACT: Parkinson's disease is a progressive neurological disorder, characterized by prominent movement dysfunction. The past two decades have seen a rapid expansion of our understanding of the genetic basis of Parkinson's, initially through the identification of monogenic forms and, more recently, through genome-wide association studies identifying common risk variants. Intriguingly, a number of cellular pathways have emerged from these analysis as playing central roles in the aetiopathogenesis of Parkinson's. In this review, the impact of data deriving from genome-wide analyses for Parkinson's upon our functional understanding of the disease will be examined, with a particular focus on examples of endo-lysosomal and mitochondrial dysfunction. The challenges of moving from a genetic to a function

SUBMITTER: Bhore N 

PROVIDER: S-EPMC10874702 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature