Measuring competitive exclusion in non-small cell lung cancer.
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ABSTRACT:
SUBMITTER: Farrokhian N
PROVIDER: S-EPMC10883359 | biostudies-literature | 2022 Jul
REPOSITORIES: biostudies-literature
Publications
Measuring competitive exclusion in non-small cell lung cancer.
Farrokhian Nathan N Maltas Jeff J Dinh Mina M Durmaz Arda A Ellsworth Patrick P Hitomi Masahiro M McClure Erin E Marusyk Andriy A Kaznatcheev Artem A Scott Jacob G JG
Science advances 20220701 26
In this study, we experimentally measure the frequency-dependent interactions between a gefitinib-resistant non-small cell lung cancer population and its sensitive ancestor via the evolutionary game assay. We show that cost of resistance is insufficient to accurately predict competitive exclusion and that frequency-dependent growth rate measurements are required. Using frequency-dependent growth rate data, we then show that gefitinib treatment results in competitive exclusion of the ancestor, wh ...[more]
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