Gut flora in multiple sclerosis: implications for pathogenesis and treatment.

ABSTRACT:

Abstract

Multiple sclerosis is an inflammatory disorder characterized by inflammation, demyelination, and neurodegeneration in the central nervous system. Although current first-line therapies can help manage symptoms and slow down disease progression, there is no cure for multiple sclerosis. The gut-brain axis refers to complex communications between the gut flora and the immune, nervous, and endocrine systems, which bridges the functions of the gut and the brain. Disruptions in the gut flora, termed dysbiosis, can lead to systemic inflammation, leaky gut syndrome, and increased susceptibility to infections. The pathogenesis of multiple sclerosis involves a combination of genetic and environmental factors, and gut flora may play a pivotal role in regulating immune responses relate

SUBMITTER: Zhang W 

PROVIDER: S-EPMC10883522 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature