Unknown

Dataset Information

0

Regulation of the Activity of the Dual Leucine Zipper Kinase by Distinct Mechanisms.


ABSTRACT: The dual leucine zipper kinase (DLK) alias mitogen-activated protein 3 kinase 12 (MAP3K12) has gained much attention in recent years. DLK belongs to the mixed lineage kinases, characterized by homology to serine/threonine and tyrosine kinase, but exerts serine/threonine kinase activity. DLK has been implicated in many diseases, including several neurodegenerative diseases, glaucoma, and diabetes mellitus. As a MAP3K, it is generally assumed that DLK becomes phosphorylated and activated by upstream signals and phosphorylates and activates itself, the downstream serine/threonine MAP2K, and, ultimately, MAPK. In addition, other mechanisms such as protein-protein interactions, proteasomal degradation, dephosphorylation by various phosphatases, palmitoylation, and subcellular localization have been shown to be involved in the regulation of DLK activity or its fine-tuning. In the present review, the diverse mechanisms regulating DLK activity will be summarized to provide better insights into DLK action and, possibly, new targets to modulate DLK function.

SUBMITTER: Koster KA 

PROVIDER: S-EPMC10886912 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature

altmetric image

Publications

Regulation of the Activity of the Dual Leucine Zipper Kinase by Distinct Mechanisms.

Köster Kyra-Alexandra KA   Dethlefs Marten M   Duque Escobar Jorge J   Oetjen Elke E  

Cells 20240211 4


The dual leucine zipper kinase (DLK) alias mitogen-activated protein 3 kinase 12 (MAP3K12) has gained much attention in recent years. DLK belongs to the mixed lineage kinases, characterized by homology to serine/threonine and tyrosine kinase, but exerts serine/threonine kinase activity. DLK has been implicated in many diseases, including several neurodegenerative diseases, glaucoma, and diabetes mellitus. As a MAP3K, it is generally assumed that DLK becomes phosphorylated and activated by upstre  ...[more]

Similar Datasets

| S-EPMC10185614 | biostudies-literature
2013-08-28 | E-GEOD-50245 | biostudies-arrayexpress
| S-EPMC3832926 | biostudies-literature
2013-08-28 | GSE50245 | GEO
| S-EPMC3724675 | biostudies-literature
| S-EPMC5404924 | biostudies-literature
| S-EPMC3383631 | biostudies-literature
| S-EPMC3672216 | biostudies-literature
| S-EPMC6029846 | biostudies-literature
| S-EPMC4965899 | biostudies-literature