A General Mechanism for the General Stress Response in Bacteria.

ABSTRACT: Bacteria have a widely conserved General Stress Response (GSR) that allows them to survive adverse environmental conditions. However, because the signaling proteins that initiate the GSR have evolved to respond to a vast range of species-specific signals, we lack a general understanding of how they are controlled. Here, we determined the molecular mechanism by which a member of the PPM family of protein serine/threonine phosphatases, RsbU, activates the GSR in B. subtilis. It was known that the phosphatase activity of RsbU is activated through interaction with a partner protein, RsbT, when it is released from a megadalton stress-sensing complex upon environmental stress, but how RsbT activates RsbU was not understood. Here we report that RsbT binds an otherwise flexible linker of Rs

SUBMITTER: Baral R 

PROVIDER: S-EPMC10889023 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature