Germline Mutations and Ancestry in Prostate Cancer.

ABSTRACT:

Purpose of review

Prostate cancer is the most frequently diagnosed non-cutaneous malignancy of men in the USA; notably, the incidence is higher among men of African, followed by European and Asian ancestry. Germline mutations and, in particular, mutations in DNA damage repair genes (DDRGs) have been implicated in the pathogenesis of prostate cancer. This review intends to discuss the implication of ancestry on prostate cancer, specifically in regard to lack of diversity in genomic and genetic databases and the ability of providers to properly counsel patients on the significance of cancer genetic results.

Recent findings

Ancestral differences in prostate cancer-associated DDRG germline mutations are increasingly recognized. Guidelines for treatment by the National Comprehens

SUBMITTER: Bataba E 

PROVIDER: S-EPMC10891190 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature