Dataset Information

Machine learning predicts the risk of osteoporosis in patients with breast cancer and healthy women.

ABSTRACT:

Objective

In this study, we investigated the effects of endocrine therapy and related drugs on the body composition and bone metabolism of patients with breast cancer. Additionally, using body composition-related indicators in machine learning algorithms, the risks of osteoporosis in patients with breast cancer and healthy women were predicted.

Methods

We enrolled postmenopausal patients with breast cancer who were hospitalized in a tertiary hospital and postmenopausal women undergoing health checkups in our hospital between 2019 and 2021. The basic information, body composition, bone density-related indicators, and bone metabolism-related indicators of all the study subjects were recorded. Machine learning models were constructed using cross-validation.

Results

Compared with a healthy population, the body composition of patients with breast cancer was low in bone mass, protein, body fat percentage, muscle, and basal metabolism, whereas total water, intracellular fluid, extracellular fluid, and waist-to-hip ratio were high. In patients with breast cancer, the bone mineral density (BMD), Z value, and T value were low and the proportion of bone loss and osteoporosis was high. BMD in patients with breast cancer was negatively correlated with age, endocrine therapy status, duration of medication, and duration of menopause, and it was positively correlated with body mass index (BMI) and basal metabolism. The parameters including body composition, age, hormone receptor status, and medication type were used for developing the machine learning model to predict osteoporosis risk in patients with breast cancer and healthy populations. The model showed a high accuracy in predicting osteoporosis, reflecting the predictive value of the model.

Conclusions

Patients with breast cancer may have changed body composition and BMD. Compared with the healthy population, the main indicators of osteoporosis in patients with breast cancer were reduced nonadipose tissue, increased risk of edema, altered fat distribution, and reduced BMD. In addition to age, duration of treatment, and duration of menopause, body composition-related indicators such as BMI and basal metabolism may be considerably associated with BMD of patients with breast cancer, suggesting that BMD status can be monitored in clinical practice by focusing on changes in the aforementioned indexes, which may provide a way to prevent preclinical osteoporosis.

SUBMITTER: Zhao F

PROVIDER: S-EPMC10891247 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature

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Publications

Machine learning predicts the risk of osteoporosis in patients with breast cancer and healthy women.

Zhao Fang F Li Chaofan C Wang Weiwei W Zhang Yu Y Yao Peizhuo P Wei Xinyu X Jia Yiwei Y Dang Shaonong S Zhang Shuqun S

Journal of cancer research and clinical oncology 20240223 2

<h4>Objective</h4>In this study, we investigated the effects of endocrine therapy and related drugs on the body composition and bone metabolism of patients with breast cancer. Additionally, using body composition-related indicators in machine learning algorithms, the risks of osteoporosis in patients with breast cancer and healthy women were predicted.<h4>Methods</h4>We enrolled postmenopausal patients with breast cancer who were hospitalized in a tertiary hospital and postmenopausal women under ...[more]

PMID: 38393381

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Project description:Objective Predictive models for the occurrence of cancer symptoms by using machine learning (ML) algorithms could be used to aid clinical decision-making in order to enhance the quality of cancer care. This study aimed to develop and validate a selection of classification models that used ML algorithms to predict the occurrence of breast cancer-related lymphedema (BCRL) among Chinese women. Methods This was a retrospective cohort study of consecutive cases that had been diagnosed with breast cancer, stages I-IV. Forty-eight variables were grouped into five feature sets. Five classification models with ML algorithms were developed, and the models' performance and the variables’ relative importance were assessed accordingly. Results Of 370 eligible female participants, 91 had BCRL (24.6%). The mean age of this study sample was 49.89 (SD = 7.45). All participants had had breast cancer surgery, and more than half of them had had a modified radical mastectomy (n = 206, 55.5%). The mean follow-up time after breast cancer surgery was 28.73 months (SD = 11.71). Most of the tumors were either stage I (n = 49, 31.2%) or stage II (n = 252, 68.1%). More than half of the sample had had postoperative chemotherapy (n = 227, 61.4%). Overall, the logistic regression model achieved the best performance in terms of accuracy (91.6%), precision (82.1%), and recall (91.4%) for BCRL. Although this study included 48 predicting variables, we found that the five models required only 22 variables to achieve predictive performance. The most important variable was the number of positive lymph nodes, followed in descending order by the BCRL occurring on the same side as the surgery, a history of sentinel lymph node biopsy, a dietary preference for meat and fried food, and an exercise frequency of less than three times per week. These factors were the most influential predictors for enhancing the ML models’ performance. Conclusions This study found that in the ML training dataset, the multilayer perceptron model and the logistic regression model were the best discrimination models for predicting the outcome of BCRL, and the k-nearest neighbors and support vector machine models demonstrated good calibration performance in the ML validation dataset. Future research will need to use large-sample datasets to establish a more robust ML model for predicting BCRL deeply and reliably.

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Dataset Information

Machine learning predicts the risk of osteoporosis in patients with breast cancer and healthy women.

Objective

Methods

Results

Conclusions

Publications

Machine learning predicts the risk of osteoporosis in patients with breast cancer and healthy women.

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