LIGHT regulated gene expression in rheumatoid synovial fibroblasts.

ABSTRACT:

Background

Synovial hyperplasia caused by rheumatoid arthritis (RA), an autoimmune inflammatory disease, leads to the destruction of the articular cartilage and bone. A member of the tumor necrosis factor superfamily, Lymphotoxin-related inducible ligand that competes for glycoprotein D binding to herpes virus entry mediator on T cells (LIGHT) has been shown to correlate with the pathogenesis of RA.

Methods

We used cDNA microarray analysis to compare the expression of genes in rheumatoid fibroblast-like synoviocytes with and without LIGHT stimulation.

Results

Significant changes in gene expression (P-values < 0.05 and fold change ≥ 2.0) were associated mainly with biological function categories of glycoprotein, glycosylation site as N-linked, plasma membrane part, int

SUBMITTER: Fukuda K 

PROVIDER: S-EPMC10894125 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature