Identifying genetic differences between bipolar disorder and major depression through multiple GWAS.

ABSTRACT:

Background

Accurate diagnosis of bipolar disorder (BD) is difficult in clinical practice, with an average delay between symptom onset and diagnosis of about 7 years. A key reason is that the first manic episode is often preceded by a depressive one, making it difficult to distinguish BD from unipolar major depressive disorder (MDD).

Aims

Here, we use genome-wide association analyses (GWAS) to identify differential genetic factors and to develop predictors based on polygenic risk scores that may aid early differential diagnosis.

Methods

Based on individual genotypes from case-control cohorts of BD and MDD shared through the Psychiatric Genomics Consortium, we compile case-case-control cohorts, applying a careful merging and quality control procedure. In a resulting coh

SUBMITTER: Panagiotaropoulou G 

PROVIDER: S-EPMC10896417 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature