Dataset Information

Longitudinal change in memory performance as a strong endophenotype for Alzheimer's disease.

ABSTRACT:

Introduction

Although large-scale genome-wide association studies (GWAS) have been conducted on AD, few have been conducted on continuous measures of memory performance and memory decline.

Methods

We conducted a cross-ancestry GWAS on memory performance (in 27,633 participants) and memory decline (in 22,365 participants; 129,201 observations) by leveraging harmonized cognitive data from four aging cohorts.

Results

We found high heritability for two ancestry backgrounds. Further, we found a novel ancestry locus for memory decline on chromosome 4 (rs6848524) and three loci in the non-Hispanic Black ancestry group for memory performance on chromosomes 2 (rs111471504), 7 (rs4142249), and 15 (rs74381744). In our gene-level analysis, we found novel genes for memory decline on chromosomes 1 (SLC25A44), 11 (BSX), and 15 (DPP8). Memory performance and memory decline shared genetic architecture with AD-related traits, neuropsychiatric traits, and autoimmune traits.

Discussion

We discovered several novel loci, genes, and genetic correlations associated with late-life memory performance and decline.

Highlights

Late-life memory has high heritability that is similar across ancestries. We discovered four novel variants associated with late-life memory. We identified four novel genes associated with late-life memory. Late-life memory shares genetic architecture with psychiatric/autoimmune traits.

SUBMITTER: Archer DB

PROVIDER: S-EPMC10896586 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature

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Publications

Longitudinal change in memory performance as a strong endophenotype for Alzheimer's disease.

Archer Derek B DB Eissman Jaclyn M JM Mukherjee Shubhabrata S Lee Michael L ML Choi Seo-Eun SE Scollard Phoebe P Trittschuh Emily H EH Mez Jesse B JB Bush William S WS Kunkle Brian W BW Naj Adam C AC Gifford Katherine A KA Cuccaro Michael L ML Pericak-Vance Margaret A MA Farrer Lindsay A LA Wang Li-San LS Schellenberg Gerard D GD Mayeux Richard P RP Haines Jonathan L JL Jefferson Angela L AL Kukull Walter A WA Keene C Dirk CD Saykin Andrew J AJ Thompson Paul M PM Martin Eden R ER Bennett David A DA Barnes Lisa L LL Schneider Julie A JA Crane Paul K PK Dumitrescu Logan L Hohman Timothy J TJ

Alzheimer's & dementia : the journal of the Alzheimer's Association 20231120 2

<h4>Introduction</h4>Although large-scale genome-wide association studies (GWAS) have been conducted on AD, few have been conducted on continuous measures of memory performance and memory decline.<h4>Methods</h4>We conducted a cross-ancestry GWAS on memory performance (in 27,633 participants) and memory decline (in 22,365 participants; 129,201 observations) by leveraging harmonized cognitive data from four aging cohorts.<h4>Results</h4>We found high heritability for two ancestry backgrounds. Fur ...[more]

PMID: 37985223

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Dataset Information

Longitudinal change in memory performance as a strong endophenotype for Alzheimer's disease.

Introduction

Methods

Results

Discussion

Highlights

Publications

Longitudinal change in memory performance as a strong endophenotype for Alzheimer's disease.

Similar Datasets

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