Associations of Autism Spectrum Disorder with PM_2.5 Components: A Comparative Study Using Two Different Exposure Models.

ABSTRACT: This retrospective cohort study examined associations of autism spectrum disorder (ASD) with prenatal exposure to major fine particulate matter (PM_2.5) components estimated using two independent exposure models. The cohort included 318 750 mother-child pairs with singleton deliveries in Kaiser Permanente Southern California hospitals from 2001 to 2014 and followed until age five. ASD cases during follow-up (N = 4559) were identified by ICD codes. Prenatal exposures to PM_2.5, elemental (EC) and black carbon (BC), organic matter (OM), nitrate (NO₃^-), and sulfate (SO₄^2-) were constructed using (i) a source-oriented chemical transport model and (ii) a hybrid model. Exposures were assigned to each maternal address during t

SUBMITTER: Rahman MM 

PROVIDER: S-EPMC10898516 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature