Associations between lower extremity muscle fat fraction and motor performance in myotonic dystrophy type 2: A pilot study.

ABSTRACT:

Introduction/aims

Although muscle structure measures from magnetic resonance imaging (MRI) have been used to assess disease severity in muscular dystrophies, little is known about how these measures are affected in myotonic dystrophy type 2 (DM2). We aim to characterize lower extremity muscle fat fraction (MFF) as a potential biomarker of disease severity, and evaluate its relationship with motor performance in DM2.

Methods

3-Tesla MRIs were obtained from nine patients with DM2 and six controls using a T1W-Dixon protocol. To calculate MFF, muscle volumes were segmented from proximal, middle, and distal regions of the thigh and calf. Associations between MFF and motor performance were calculated using Spearman's correlations (ρ).

Results

Mean age of DM2 participants wa

SUBMITTER: Madrid DA 

PROVIDER: S-EPMC10898809 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature