Total Effective Xenoestrogen Burden in Serum Samples and Risk of Endometrial Cancer in the Spanish Screenwide Case-Control Study.

ABSTRACT:

Background

Endometrial cancer is a hormone-dependent cancer, and estrogens play a relevant role in its etiology. However, little is known about the effects of environmental pollutants that act as xenoestrogens or that influence estrogenic activity through different pathways.

Objective

We aimed to assess the relationship between the combined estrogenic activity of mixtures of xenoestrogens present in serum samples and the risk of endometrial cancer in the Screenwide case-control study.

Methods

The total effective xenoestrogen burden (TEXB) attributable to organohalogenated compounds (TEXB-α) and to endogenous hormones and more polar xenoestrogens (TEXB-β) was assessed in serum from 156 patients with endometrial cancer (cases) and 150 controls by combining chemical extr

SUBMITTER: Costas L 

PROVIDER: S-EPMC10901108 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature