Association of lipid-lowering drugs with osteoarthritis outcomes from a drug-target Mendelian randomization study.

ABSTRACT:

Background

Osteoarthritis (OA), a prevalent musculoskeletal disorder, has been suggested to have a potential association with metabolic syndrome, particularly lipid metabolism. Studies exploring the effects of lipid-lowering drugs on OA have yielded conflicting results.

Objective

This study employed a drug-targeted Mendelian randomization approach to investigate the association between genetically predicted lipid-modulating effects of commonly targeted lipid-lowering agents and the risk of OA, with the aim of providing a theoretical foundation for the use of lipid-lowering drugs in OA treatment.

Methods

Employing Mendelian randomization (MR) analysis, we examined the potential causal relationship between lipid-lowering drugs and OA. Genetic variants associated with LD

SUBMITTER: Ma W 

PROVIDER: S-EPMC10901306 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature