Dataset Information

A comprehensive analysis of albuminuria in canine chronic kidney disease.

ABSTRACT:

Background

Albuminuria, an important marker of decreased kidney function in chronic kidney disease (CKD), is not routinely used for CKD detection or proteinuria appearance. Its relationships with biochemical parameters and blood pressure in dogs are poorly understood.

Objectives

This study aimed to evaluate the relationship of albuminuria with various CKD markers, its correlation with the urinary protein to creatinine ratio (UPC), and hypertension in dogs with early stages of CKD. It also sought to determine the usability of the urinary albumin to creatinine ratio (UAC) for CKD screening.

Methods

The study reviewed records of 102 dogs, categorising them into four groups based on disease status. UAC and UPC ratio, biochemistry and haematology variables, age, and systolic blood pressure were determined.

Results

The Pearson's correlation coefficient between log-transformed values of UPC and UAC was r = 0.902 (95% CI: 0.87 to 0.93). Median UAC ratio values were 2.1 mg/g for the Healthy control group (n = 17), 54.2 mg/g for early stages CKD (n = 42), 5.8 mg/g for Acute sick control (n = 30), and 104 mg/g for Chronic sick control (n = 13). Thresholding UAC ratio as an indicator for impaired kidney function with the threshold of 10 mg/g (established based on the receiver operating characteristic curve) had a sensitivity 81.8%, specificity of 89.4%, positive predictive value (PPV) 90%, and negative predictive value (NPV) 80.1%. The correlation of UAC with biochemistry and haematology variables was statistically significant; for SDMA (μg/L), it was r = 0.566 and for other variables, it was weak to moderate. UAC was markedly elevated in cases of severe hypertension.

Conclusions

UAC ratio was significantly different among dogs with impaired and not impaired kidney function. The correlation strength for the UAC and UPC ratios was high. UAC ratio may be a promising marker for proteinuria analysis in dogs with CKD or other kidney function alterations.

SUBMITTER: Paukner K

PROVIDER: S-EPMC10902581 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature

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Publications

A comprehensive analysis of albuminuria in canine chronic kidney disease.

Paukner Karel K Filipejova Zita Z Mareš Jan J Vávra Miloš M Rehakova Kristina K Proks Pavel P Gabriel Vojtech V Crha Michal M

Veterinary medicine and science 20240301 2

<h4>Background</h4>Albuminuria, an important marker of decreased kidney function in chronic kidney disease (CKD), is not routinely used for CKD detection or proteinuria appearance. Its relationships with biochemical parameters and blood pressure in dogs are poorly understood.<h4>Objectives</h4>This study aimed to evaluate the relationship of albuminuria with various CKD markers, its correlation with the urinary protein to creatinine ratio (UPC), and hypertension in dogs with early stages of CKD. ...[more]

PMID: 38419297

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Dataset Information

A comprehensive analysis of albuminuria in canine chronic kidney disease.

Background

Objectives

Methods

Results

Conclusions

Publications

A comprehensive analysis of albuminuria in canine chronic kidney disease.

Similar Datasets

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