Long-term cardiovascular risks and the impact of statin treatment on socioeconomic inequalities: a microsimulation model.

ABSTRACT:

Background

UK cardiovascular disease (CVD) incidence and mortality have declined in recent decades but socioeconomic inequalities persist.

Aim

To present a new CVD model, and project health outcomes and the impact of guideline-recommended statin treatment across quintiles of socioeconomic deprivation in the UK.

Design and setting

A lifetime microsimulation model was developed using 117 896 participants in 16 statin trials, 501 854 UK Biobank (UKB) participants, and quality-of-life data from national health surveys.

Method

A CVD microsimulation model was developed using risk equations for myocardial infarction, stroke, coronary revascularisation, cancer, and vascular and non-vascular death, estimated using trial data. The authors calibrated and further developed

SUBMITTER: Wu R 

PROVIDER: S-EPMC10904120 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature