Bispecific antibodies promote natural killer cell-mediated elimination of HIV-1 reservoir cells.

ABSTRACT: The persistence of CD4⁺ T cells carrying latent human immunodeficiency virus-1 (HIV-1) proviruses is the main barrier to a cure. New therapeutics to enhance HIV-1-specific immune responses and clear infected cells will probably be necessary to achieve reduction of the latent reservoir. In the present study, we report two single-chain diabodies (scDbs) that target the HIV-1 envelope protein (Env) and the human type III Fcγ receptor (CD16). We show that the scDbs promoted robust and HIV-1-specific natural killer (NK) cell activation and NK cell-mediated lysis of infected cells. Cocultures of CD4⁺ T cells from people with HIV-1 on antiretroviral therapy (ART) with autologous NK cells and the scDbs resulted in marked elimination of reservoir cells that was dependent on la

SUBMITTER: Board NL 

PROVIDER: S-EPMC10907297 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature