OCA-B/Pou2af1 is sufficient to promote CD4⁺ T cell memory and prospectively identifies memory precursors.

ABSTRACT: The molecular mechanisms leading to the establishment of immunological memory are inadequately understood, limiting the development of effective vaccines and durable antitumor immune therapies. Here, we show that ectopic OCA-B expression is sufficient to improve antiviral memory recall responses, while having minimal effects on primary effector responses. At peak viral response, short-lived effector T cell populations are expanded but show increased Gadd45b and Socs2 expression, while memory precursor effector cells show increased expression of Bcl2, Il7r, and Tcf7 on a per-cell basis. Using an OCA-B mCherry reporter mouse line, we observe high OCA-B expression in CD4⁺ central memory T cells. We show that early in viral infection, endogenously

SUBMITTER: Sun W 

PROVIDER: S-EPMC10907311 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature